反应详情

温度

110 °C

A 70% aqueous ethylamine solution (40 ml) was added to a solution (70 ml) of 7-chloro-6-nitro-4(3H)-quinazolone (6.31 g, 28.0 mmol) in ethanol and the mixture was heated with stirring at 110° C. for 4 hours in a sealed tube. After cooling to room temperature, the reaction mixture was poured into water and the precipitated crystals were collected by filtration. The crystals were washed with ethanol and dried to give the title compound (2.6 g, 39%).

1. temperaturethe mixture was heated
2. temperatureAfter cooling to room temperature
3. filtrationthe precipitated crystals were collected by filtration
4. washThe crystals were washed with ethanol
5. customdried