Water → HCID 135430303, compound

HRID 1939945Notes

Reaction equation

HRID 1939945 reaction equation
[CH2:1]([NH2:3])[CH3:2].Cl[C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17].O>C(O)C>[CH2:1]([NH:3][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 1356875047-Chloro-6-nitroquinazolin-4(1H)-one

Product 1

HCID 135430303HCID 135430303, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

A 70% aqueous ethylamine solution (40 ml) was added to a solution (70 ml) of 7-chloro-6-nitro-4(3H)-quinazolone (6.31 g, 28.0 mmol) in ethanol and the mixture was heated with stirring at 110° C. for 4 hours in a sealed tube. After cooling to room temperature, the reaction mixture was poured into water and the precipitated crystals were collected by filtration. The crystals were washed with ethanol and dried to give the title compound (2.6 g, 39%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling to room temperature
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-98ede638025a4444b87a0b2bdaaf47c0
Source dataset
uspto-grants-1997_12
Patent number
US05698560

Reaction notes

Loading…