4-[3-(4-Morpholinyl)propoxy]benzonitrile → HCID 21465325, compound

HRID 1939956Notes

Reaction equation

HRID 1939956 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][C:14]([CH2:15][NH2:16])=[CH:13][CH:12]=2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 29938364-[3-(4-Morpholinyl)propoxy]benzonitrileHCID 21226445Aluminium lithium hydride

Product 1

HCID 21465325HCID 21465325, compoundYield 100%

Procedure

According to a similar manner as that in Reference Example 78, 4-(3-morpholinopropoxy)benzonitrile obtained above was reduced by lithium aluminium hydride to give the title compound (100%). This compound was used in the subsequent reaction without further purification.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-2f119fac32ac4f7489833fb84089fa08
Source dataset
uspto-grants-1997_12
Patent number
US05698560

Reaction notes

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