HCID 2995544, compound → HCID 21465330, compound

HRID 1939958Notes

Reaction equation

HRID 1939958 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:16][NH2:17])=[CH:18][CH:19]=2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 2995544HCID 2995544, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 21465330HCID 21465330, compoundYield 88%

Procedure

According to a similar manner as that in Reference Example 78, 4-(4-morpholinobutoxy)benzonitrile obtained above was reduced by lithium aluminium hydride to give the title compound (88%). This compound was used in the subsequent reaction without further purification.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-48917cb0938942e289d88d846a30753d
Source dataset
uspto-grants-1997_12
Patent number
US05698560

Reaction notes

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