6-Bromohexanamide → 9-(4-Pyridinylmethyl)-9H-fluoren-9-butanamide Hemihydrate
Reaction equation
BrCC[CH2:4][CH2:5][CH2:6][C:7]([NH2:9])=[O:8].[N:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]2[C:29]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:23]3[C:18]2=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:12][CH:11]=1>>[OH2:8].[N:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]2([CH2:4][CH2:5][CH2:6][C:7]([NH2:9])=[O:8])[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=3[C:24]3[C:29]2=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:14][CH:15]=1.[N:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]2([CH2:4][CH2:5][CH2:6][C:7]([NH2:9])=[O:8])[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=3[C:24]3[C:29]2=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:14][CH:15]=1Participants
3
Procedure
By substituting 4-bromobutyl acetamide and 9-(4-pyridinylmethyl)-9H-fluorene in Ex. 1, the product was obtained in 100% yield; mp 50°-52° C.
Workup
- custom1, the product was obtained in 100% yield
Sources & evidence
- ORD record
- ord-65585d37b058491383e6a5189106d7b4
- Source dataset
- uspto-grants-1997_12
- Patent number
- US05698559
Reaction notes
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