Potassium Carbonate → HCID 15347206, compound

Participants

Reaction Steps

12.5 g (0.058 mol) of 2-chioromethylquinoline hydrochloride, 9.8 g of 3-hydroxyphenylethanol, 8 g of potassium carbonate, 8 g of sodium hydroxide, 150 ml of methylene chloride and 5 g of Adogene 624 are introduced into a flask. Stirring is carded out at room temperature for 16 hours. The mixture is washed with water, dried over sodium sulphate and concentrated to dryness. The residue is chromatographed on 1.5 litres of silica using a methylene chloride/methanol mixture (98/2) as eluant. There are obtained 8.6 g of 2-[3-(quinol-2-ylmethoxy)-phenyl]ethanol. Yield: 53%.

Provenance & Evidence