Bromine → HCID 15347207, compound

Participants

Reaction Steps

8.6 g of 2-[3-(quinol-2-ylmethoxy)phenyl]ethanol are dissolved in 200 ml of methylene chloride. There are added 9.8 g of tdphenylphosphine and then, at 10° C., 1.9 g of bromine dissolved in 50 ml of methylene chloride. Stirring is carded out at room temperature for 16 hours. The mixture is concentrated to dryness and the residue is taken up in ether. The mixture is washed with a 10% sodium carbonate solution and dried over sodium sulphate. Concentration to dryness is carded out. The residue is chromatographed on 450 g of silica using methylene chloride as eluant. There are obtained 7.7 g of 1-bromo-2-[3-(quinol-2-yl-methoxy) phenyl]ethane. Yield: 72%.

Provenance & Evidence