HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1940022Generated: November 1, 2026
Hydrochloric Acid → 5-Bromothiophene-2-carboxylic acid
https://huagongshe.com/reaction/1940022
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 172461-89-1 | HCID 21465636 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromothiophene-2-carboxylic acid | HCID 349115 | 172.9% |
Reaction Steps
27.5 g of sodium sulfite are dissolved in 300 ml of water, and a total of 35 g of 5-bromo-4-chlorosulfonylthiophene-2-carboxylic acid is added, in portions, at 70° C., with a pH of 9-11 being maintained using 10N NaOH. The mixture is subsequently stirred at 70° C. for 2 h and then adjusted to pH=1 with HCl, after which the product is filtered off with suction. 41 g of colorless crystals are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05698581 |
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| Source dataset | uspto-grants-1997_12 |
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| ORD ID | ord-eeec85c405a441ab85f09245455a2561 |
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| Source note | uspto-grants-1997_12 |
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