HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-chloroacetylcarbamoyl fumagillol → Fumagillol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-chloroacetylcarbamoyl fumagillol | HCID 14942883 | — |
| Reactant | HCID 178483734 | HCID 178483734 | — |
| Product | Fumagillol | HCID 222778 | 158.4% |
Reaction Steps
In the same manner as in Example 42, O-chloroacetylcarbamoylfumagillol (195 mg) was reacted with 1-(2-dimethylaminoethyl)-5-mercaptotetrazole sodium (113 mg) with stirring at room temperature for 1 hour. Purification by silica gel column chromatography (eluent: ethyl acetate) gave colorless, powdery O-[[1-(2-dimethylaminoethyl)tetrazol]-5-yl)thioacetylcarbamoyl]fumagillol (217 mg) (83% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05698586 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-b79d48a4ceb64144b11c35448621a62d |
| Source note | uspto-grants-1997_12 |