Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

HRID 1940040Notes

Reaction equation

HRID 1940040 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([O-])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH3:13])=[O:11].S(Cl)([Cl:16])=O>>[C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([Cl:16])=[O:8])=[CH:6][N:1]=1)([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 425561312,5-Pyridinedicarboxylic acid, 2-methyl ester

Product 1

HCID 151211775-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

Procedure

In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester 10 (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride 11.

Sources & evidence

ORD record
ord-2cdc6e492c114b8ab6017287690f384f
Source dataset
uspto-grants-1997_12
Patent number
US05698523

Reaction notes

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