HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 2-(1-Sulfonylamino-2-methylphenyl)ethylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | p-Methylphenethylamine | HCID 76751 | — |
| Reactant | 2,2,2-Trichloro-n-methylacetamide | HCID 248652 | — |
| Reactant | 2,5-Difluorobenzoyl chloride | HCID 588082 | — |
| Product | 2-(1-Sulfonylamino-2-methylphenyl)ethylamine hydrochloride | HCID 86585205 | — |
Reaction Steps
2-(1-Sulfonylamino-2-methylphenyl)ethylamine hydrochloride, which is synthesized in accordance with Example 4 from 2-(p-tolyl)ethylamine, can be converted into 2,5-difluoro-N-{5-[1-sulfonylamino-N-(methylaminocarbonyl)-2-methylphenyl]-ethyl}-benzamide, melting point: 196°-198° C., as described first with 2,5-difluorobenzoyl chloride and then with N-methyltrichloroacetamide and sodium hydroxide in dimethyl sulfoxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05698596 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-74fc38b0a5d442b3be60522e20193911 |
| Source note | uspto-grants-1997_12 |