HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1940163Generated: October 26, 2026
1-Cyclopropylethanol → 3-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone
https://huagongshe.com/reaction/1940163
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Cyclopropylethanol | HCID 79104 | — |
| Reactant | 3-Diazofuran-2,4-dione | HCID 15439113 | — |
| Catalyst | Rhodium acetate | HCID 168478 | — |
| Product | 3-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone | HCID 70106454 | — |
Reaction Steps
To the mixture of 3-diazo-2,4-(3H,5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and α-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2) to provide 50 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05698584 |
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| Source dataset | uspto-grants-1997_12 |
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| ORD ID | ord-596ffeb103954e4282aadef7a0cbe3b1 |
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| Source note | uspto-grants-1997_12 |
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