1-Bromo-2-methylpropane → HCID 53746354, compound

HRID 1940191Notes

Reaction equation

HRID 1940191 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C@H:5]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[NH:7][C:6]1=[O:24].[CH2:26](Br)[CH:27]([CH3:29])[CH3:28]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C@H:5]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[N:7]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:6]1=[O:24]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 54353505HCID 54353505, compound

Product 1

HCID 53746354HCID 53746354, compoundYield 52.2%

Procedure

(3R)-7-Chloro-5-(2-chlorophenyl)-2,3-dihydro-2-oxo-1H,1,4-benzodiazepine-3-acetic acid methyl ester (0.5 g) obtained in Example 11 and isobutyl bromide (0.23 g) were allowed to proceed in substantially the same manner as in Example 4 to give 0.3 g of a colorless oily compound.

Sources & evidence

ORD record
ord-596763685f4d4ae5954b7197d36469eb
Source dataset
uspto-grants-1997_12
Patent number
US05698691

Reaction notes

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