Hydrochloric Acid → HCID 21465899, compound

Participants

Reaction Steps

To a solution of 7-chloro-5-(2-chlorophenyl)-1-neopentyl-1,2-dihydro-2-oxo-3H-1,3,4-benzotriazepine-3-acetic acid ethyl ester obtained in Example 56 (0.16 g) in ethanol (3 ml) was added a 1N aqueous solution of sodium hydroxide (0.3 ml). The mixture was stirred for 4 hours at room temperature. To the reaction mixture was added water (50 ml), which was made acid with 1N HCl, then the solution was concentrated. To the concentrate was added dichloromethane (50 ml), which was washed with water, then the solvent was distilled off. The residue was recrystallized from dichloromethane--petroleum ether to give 91 mg of colorless crystals, m.p. 181°-183° C.

Provenance & Evidence