Hydrochloric Acid → HCID 10447045, compound

Participants

Reaction Steps

To a solution of 5-hydroxy-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-carboxylic acid (25.03 g, 100 mmol) in pyridine (200 mL) is added acetic anhydride (100 mL) and the mixture is stirred at room temperature for 24 hrs. Water and ice are added and the mixture is stirred at about 30° C. for 30 min. The mixture is cooled in ice and 6N hydrochloric acid (450 mL) is added. The resulting solid is collected, washed with water, taken up in ethyl acetate. The organic layer is washed with 2N hydrochloric acid and water, dried (sodium sulfate) and evaporated to dryness. Recrystallization from ethyl acetate gave 23.6 g (81%) of 5-acetoxy-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-carboxylic acid (mp=187° C.-188° C.).

Provenance & Evidence