HuagongsheHuagongshe Chemistry Print Report · For research reference only
Mesitylene → 2,4,6-Trimethylphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Mesitylene | HCID 7947 | — |
| Reactant | Acetonitrile, [(phenylsulfonyl)oxy]- | HCID 82705 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 2,4,6-Trimethylphenylacetonitrile | HCID 520698 | 72.3% |
Reaction Steps
8.0 g (0.06 mol) of aluminum chloride are first introduced into 40 ml of mesitylene at 0° C. 4.1 g (0.02 mol) of phenylsulfonyloxyacetonitrile are then added, and the reaction mixture is stirred at room temperature overnight. The crude product obtained after hydrolysis is chromatographed on silica gel using dichloromethane. 2.3 g (72.3% of theory) of 2,4,6-trimethylbenzyl cyanide are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05698735 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-58a50835298246788cd73efc178141a8 |
| Source note | uspto-grants-1997_12 |