Hydrochloric Acid → Phenylacetic Acid

Participants

Reaction Steps

19.15 g (0.144 mol) of aluminum chloride are first introduced into 70 ml of benzene at 40°-50° C., and 10 g (0.048 mol) of n-butyl methanesulfonyloxyacetate are then added. The mixture is additionally stirred overnight, hydrolyzed with 10% hydrochloric acid and worked up by the method of Examples 6 to 9. The crude product obtained is refluxed together with 6 g of NaOH in 15 ml of water and 50 ml of methanol for 5 hours. Further workup is carried out as in Examples 6 to 9. 5.17 g (90.3% of theory) of phenylacetic acid are isolated.

Provenance & Evidence