Thionyl Chloride → HCID 21187863, compound

HRID 1940320Notes

Reaction equation

HRID 1940320 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH:17]([F:19])[F:18])[C:10](O)=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:22])=O>C1(C)C=CC=CC=1>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH:17]([F:19])[F:18])[C:10]([Cl:22])=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21187882HCID 21187882, compound

Product 1

HCID 21187863HCID 21187863, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3-cyclopentyloxy-4-difluoromethoxybenzoic acid (0.47 g; that is prepared as described in Reference Example 42) and thionyl chloride (4 mL) in toluene (10 mL) is heated at 80° C. for 2 hours, and then evaporated under reduced pressure, to give 3-cyclopentyloxy-4-difluoromethoxybenzoyl chloride (0.48 g), in the form of a pale yellow low melting solid, which is used without further purification.

Workup

  1. customthat is prepared
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-4e96855da8e94adca45cf1674cc69f0d
Source dataset
uspto-grants-1997_12
Patent number
US05698711

Reaction notes

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