Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2H-1,2-Benzoxazin-3(4H)-one | HCID 19937448 | — |
Reaction Steps
The amino-alcohol was dissolved in THF (15 ml) and cooled to -10° C. under N2. To the mixture was added triethylamine (5.4 ml) and phosgene in toluene (4.6 ml). The addition of phosgene caused an exotherm which was maintained below 20° C. by the rate of addition. The progress of the reaction was monitored by HPLC and was typically complete in 15 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05698741 |
|---|
| Source dataset | uspto-grants-1997_12 |
|---|
| ORD ID | ord-6f244b34a3c140d3a3569c163efca1f3 |
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| Source note | uspto-grants-1997_12 |
|---|
