(S)-2-amino-1,1-di-(2'-methoxyphenyl)-4-methylpentan-1-ol acetate → Uniconazole

Participants

Reaction Steps

Reaction was carried out according to Example 1 using (S)-2-amino-1,1-diphenylpropan-1-ol hydrochloride, (S)-2-amino-1,1-diphenyl-3-methylbutan-1-ol hydrochloride, (R)-2-amino-1,1-diphenyl-3-phenylpropan-1-ol acetate and (S)-2-amino-1,1-di-(2'-methoxyphenyl)-4-methylpentan-1-ol acetate in place of (S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol hydrochloride, to obtain the (+)-isomer and (-)-isomer of (E)-1-(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-ol. The results obtained were summarized in Table 1.

Provenance & Evidence