HRID1940403

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3032233

2-(3,4-dimethoxyphenyl)propan-2-amine

C11H17NO2

结构：C[C@]12CC[C@H]3[C@@H](CC=C4C=C(C#N)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)Sc1ccccn1

HCID15380265

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(C)(C)NC(=O)[C@H]2CC[C@H]3[C@@H]4CC=C5C=C(C#N)CC[C@]5(C)[C@H]4CC[C@]23C)cc1OC

HCID57051570

未命名化合物

收率 60%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(3,4-dimethoxyphenyl)-1-methylethylamine (prepared as described in Preparation 10e) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 60%.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c81c5674282849bf967e97115603e55a
来源数据集: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05698720
来源说明: uspto-grants-1997_12

反应 SMILES

[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](=[O:30])SC2C=CC=CN=2)[CH:4]=1)#[N:2].[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:41]([NH2:44])([CH3:43])[CH3:42])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]>>[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:41]([NH:44][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:30])([CH3:42])[CH3:43])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]