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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1940406Generated: October 26, 2026

2-(4-Methylphenyl)propan-2-amine → N-[1-(4-Methylphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

https://huagongshe.com/reaction/1940406

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Methylphenyl)propan-2-amineHCID 584050—
ReactantS-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylateHCID 15380265—
ProductN-[1-(4-Methylphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamideHCID 6764669588%

Reaction Steps

Following a procedure similar to that described in Example 3(b), but using S-2pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(4-methylphenyl)-1-methylethylamine (prepared as described in Preparation 10h) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 88%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05698720
Source datasetuspto-grants-1997_12
ORD IDord-9d8b01f6d0d24d7eb9914fafbf603805
Source noteuspto-grants-1997_12