Ammonia → HCID 15293893, compound

HRID 1940454Notes

Reaction equation

HRID 1940454 reaction equation
[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:12])[CH2:6][CH2:7][CH2:8][C:9](O)=[O:10].[NH3:13]>>[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:12])[CH2:6][CH2:7][CH2:8][C:9]([NH2:13])=[O:10]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19607309HCID 19607309, compound

Product 1

HCID 15293893HCID 15293893, compound

Procedure

A solution of 9.1 g (44 mmol) of methyl ester of N-(2-mercaptoethyl)glutaramic acid obtained in Example 4a), in 100 cm3 of aqueous 20% solution of aqueous ammonia was stirred for 4 hours at ambient temperature under argon atmosphere. After evaporation to dryness and recrystallization from isopropanol 7 g of N-(2-mercaptoethyl)glutaramide were obtained in the form of a white solid with a melting point of 127° C.

Workup

  1. customAfter evaporation
  2. customto dryness and recrystallization from isopropanol 7 g of N-(2-mercaptoethyl)glutaramide
  3. customwere obtained in the form of a white solid with a melting point of 127° C.

Sources & evidence

ORD record
ord-f2603279dd5b4edfb13f261dbd41111d
Source dataset
uspto-grants-1997_12
Patent number
US05700454

Reaction notes

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