Water → HCID 21462368, compound

Participants

Reaction Steps

A solution of triphosgene (57 mg) in CH2Cl2 (1 mL) was added dropwise to a stirred solution of triethylamine (0.2 mL) and the compound of Step G, Example 3, (190 mg) in CH2Cl2 (50 mL) under N2 at room temperature. The solution was stirred at room temperature for 20 minutes. 30 mL of water was added. The organic layer was separated, dried (MgSO4) and evaporated to dryness. Flash chromatography yielded the title compound of Step H, a compound of the invention, as a white solid (127 mg), 62%; m.p. 217°-219° C.; IR (nujol, cm-1): 3253.6 and 2129.3 (C≡C), 1625 and 1715 (C=O).

Provenance & Evidence