2,3-Dimercaptopropane → HCID 21462906, compound

Participants

Reaction Steps

2.5 g (6.1 mmol) of 1-amino-3-(4-chloro-3-diethoxymethyl-phenyl)-2,4-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine, 2.0 g (18 mmol) of 1,2-propanedithiol and 50 mg of p-toluenesulfonic acid were refluxed in 100 mi of anhydrous toluene for six hours. After cooling, the mixture was washed with 10% strength sodium hydrogen carbonate solution and water, dried over sodium sulfate, concentrated and dried for 48 hours at reduced pressure. 2.1 g (80%) of a colorless oil were thus obtained, which is a 1:1 mixture of the two diastereomers.

Provenance & Evidence