2-Chloroethyl chloroformate → HCID 22100972, compound

Participants

Reaction Steps

To a solution of 1-benzyl-4-(benzothiophen-2-yl)-1,2,3,6-tetrahydropyridine (4 g, 13.1 mmol) in anhydrous dichloromethane (50 ml) at 0° C. under nitrogen was added 2-chloroethylchloroformate (1.84 ml, 17.0 mmol) and the mixture stirred for 1 hr. The reaction mixture was concentrated in vacuo and methanol (20 ml) added and the solution heated to reflux for 1 hr. After cooling the title compound was collected by filtration (2.2 g, 67%), m.p. 269° C. (dec.).

Provenance & Evidence