HCID 21463006, compound → HCID 21462999, compound

Participants

Reaction Steps

A solution of 5-phenoxyisoquinoline (1 g, 4.5 mmol) in methanol (50 ml) was shaken on a Parr hydrogenator at 55 psi hydrogen in the presence of platinum oxide (0.2 g) for 3 h. The catalyst was then removed by filtration and the solvent evaporated. The residue was triturated with hexane to give the title compound as a colourless solid (0.6 g, 60%); δH (CDCl3) 2.65-2.75 (2H, m, ArCH2CH2N), 3.1-3.2 (2H, m, ArCH2CH2N), 4.05 (2H, br s, ArCH2N), 6.75 (1H, d, J 8 Hz, ArH), 6.83 (1H, d, J 8 Hz, ArH), and 6.9-7.35 (6H, m, ArH); m/z (CI+, NH3) 226 (M+1)+.

Provenance & Evidence