Sodium Hydroxide → 4-(2,3-Dimethoxyphenyl)4-piperidinylmethanone

HRID 1940577Notes

Reaction equation

HRID 1940577 reaction equation
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.[OH-].[Na+]>O>[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 218981094-(2,3-Dimethoxyphenyl)-4-piperidinylmethanone trifluoroacetate

Product 1

HCID 218981034-(2,3-Dimethoxyphenyl)4-piperidinylmethanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The resulting 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone trifluoroacetate was dissolved in water, treated with NaOH (10% aqueous) until basic, and extracted three times with dichloromethane. The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated to afford 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone as an oil.

Workup

  1. extractionextracted three times with dichloromethane
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-1f5598083a7e4ca4ac5b3dec4579c0e8
Source dataset
uspto-grants-1997_12
Patent number
US05700812

Reaction notes

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