反应详情

A solution of 7-(trifluoroacetylamino)-2,3-dihydrobenzofuran (D2) (1.6 g) in methanol (30 ml) and 10% NaOH (3 ml) was heated to reflux for 24h. The mixture was evaporated under reduced pressure and partitioned between ethyl acetate and water. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (900 mg, 96%) as a pale orange oil, which crystallised on standing.

1. temperatureto reflux for 24h
2. customThe mixture was evaporated under reduced pressure
3. custompartitioned between ethyl acetate and water
4. dry with materialThe organic phase was dried (Na2SO4)
5. customthe solvent evaporated under reduced pressure