Water → HCID 21463487, compound

Participants

Reaction Steps

A solution of 1-(5-amino-2,3-dihydrobenzofuran-7-yl)-3-dimethylamino- propene-1-one (D14) (400 mg) in dry tetrahydrofuran (9 ml) was added to a stirred suspension of lithium aluminium hydride (46 mg) in dry tetrahydrofuran (9 ml) at 0° C. under argon. The mixture was stirred at this temperature for 1/4 h then treated sequentially with water (0.046 ml), 10% NaOH (0.068 ml) and water (0.12 ml). After a further 1/4 h stirring at room temperature the mixture was filtered through kieselguhr, and washed with dry tetrahydrofuran, and the solvent was evaporated under reduced pressure to give the title compound as a yellow/orange solid (352 mg, 87%).

Provenance & Evidence