HCID 21463508, compound → HCID 21463515, compound

HRID 1940632Notes

Reaction equation

HRID 1940632 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][C:13](O)=O)[CH:7]=1)[CH3:2].Cl.[NH2:18][C:19]1[C:24]([Cl:25])=[C:23]([Cl:26])[CH:22]=[CH:21][C:20]=1[SH:27]>>[Cl:25][C:24]1[C:19]2[N:18]=[C:13]([CH2:12][C:8]3[CH:7]=[C:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:16])[CH:11]=[CH:10][CH:9]=3)[S:27][C:20]=2[CH:21]=[CH:22][C:23]=1[Cl:26]

Participants

3

Reactant 2

HCID 21463508HCID 21463508, compoundHCID 23086838[3-(2-ethoxy-2-oxoethyl)phenyl]acetic Acid

Product 1

HCID 21463515HCID 21463515, compoundYield 56.3%

Procedure

The procedure of Example 16-i) was repeated using 1,3-phenylene diacetic acid monoethyl ester (847 mg, 3.3 mmol) and 2-amino-3,4-dichlorothiophenol hydrochloride (831 mg, 4.3 mmol) to obtain ethyl 3-[(4,5-dichlorobenzothiazol-2-yl)methyl]phenylacetate (706 mg, 56%) as a pale yellow oil.

Sources & evidence

ORD record
ord-d8e50cb332c64d17bff6f2a3448dc75f
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

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