2,2'-(5-Methyl-1,3-phenylene)diacetonitrile → HCID 21463527, compound

HRID 1940634Notes

Reaction equation

HRID 1940634 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH2:11][C:12]#[N:13])[CH:5]=1)#[N:2].Cl.N[C:16]1[C:21]([F:22])=[C:20]([F:23])[CH:19]=[CH:18][C:17]=1[SH:24]>>[F:22][C:21]1[C:16]2[N:13]=[C:12]([CH2:11][C:6]3[CH:5]=[C:4]([CH2:3][C:1]#[N:2])[CH:9]=[C:8]([CH3:10])[CH:7]=3)[S:24][C:17]=2[CH:18]=[CH:19][C:20]=1[F:23]

Participants

3

Reactant 2

HCID 193493962,2'-(5-Methyl-1,3-phenylene)diacetonitrileHCID 21463514HCID 21463514, compound

Product 1

HCID 21463527HCID 21463527, compoundYield 17%

Procedure

The procedure of Example 22-i) was repeated using 1,3-biscyanomethyl-5-methylbenzene (680 mg, 4 mmol) and 2-amino-3,4-difluorothiophenol hydrochloride (888 mg, 4.5 mmol) and the resultant product was recrystallized from ethyl acetate-hexane to give 3-[(4,5-difluorobenzothiazol-2-yl)methyl]-5-methylphenylacetonitrile (210 mg, 17%) as a colorless powder.

Workup

  1. customthe resultant product was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-5926fa79ce2d4807b15303f22d638d0d
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

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