Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochloride → HCID 21463510, compound

HRID 1940636Notes

Reaction equation

HRID 1940636 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[C:5]=1[Cl:13])#[N:2].Cl.N[C:16]1[C:21]([F:22])=[C:20]([F:23])[CH:19]=[C:18]([F:24])[C:17]=1[SH:25]>>[F:22][C:21]1[C:16]2[N:2]=[C:1]([CH2:3][C:4]3[C:5]([Cl:13])=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=3)[S:25][C:17]=2[C:18]([F:24])=[CH:19][C:20]=1[F:23]

Participants

3

Reactant 2

HCID 11390282Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochlorideHCID 56997307HCID 56997307, compound

Product 1

HCID 21463510HCID 21463510, compoundYield 23.2%

Procedure

The procedure of Example 22-i) was repeated using 1,3-biscyanomethyl-2-chlorobenzene (953 mg, 5 mmol) and 2-amino-3,4,6-trifluorothiophenol hydrochloride (1,078 mg, 10 mmol) and the resultant product was crystallized from ethyl acetate-hexane to give 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-2-chlorophenylacetonitrile (410 mg, 23%) as a colorless powder.

Workup

  1. customthe resultant product was crystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-ab4a7b569a2a446ea4107bc3dc4c04ac
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

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