Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochloride → HCID 21463499, compound

HRID 1940639Notes

Reaction equation

HRID 1940639 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([CH2:11][C:12]#[N:13])[CH:5]=1)#[N:2].Cl.N[C:16]1[C:21]([F:22])=[C:20]([F:23])[CH:19]=[C:18]([F:24])[C:17]=1[SH:25]>>[F:22][C:21]1[C:16]2[N:2]=[C:1]([CH2:3][C:4]3[CH:5]=[C:6]([CH2:11][C:12]#[N:13])[CH:7]=[C:8]([Br:10])[CH:9]=3)[S:25][C:17]=2[C:18]([F:24])=[CH:19][C:20]=1[F:23]

Participants

3

Reactant 2

HCID 11390282Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochlorideHCID 57055454HCID 57055454, compound

Product 1

HCID 21463499HCID 21463499, compoundYield 18%

Procedure

The procedure of Example 22-i) was repeated using 1,3-biscyanomethyl-5-bromobenzene (1.9 g, 8.1 mmol) and 2-amino-3,4,6-trifluorothiophenol hydrochloride (1.74 g, 8.1 mmol) and the resultant product was crystallized from isopropyl ether to give 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-5-bromophenylacetonitrile (532 mg, 18%) as a colorless powder.

Workup

  1. customthe resultant product was crystallized from isopropyl ether

Sources & evidence

ORD record
ord-02423317a10645bf8dfbef42771c7cee
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

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