Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochloride → HCID 21463536, compound

HRID 1940641Notes

Reaction equation

HRID 1940641 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[C:8]([N:10]([CH3:12])[CH3:11])[CH:7]=[C:6]([CH2:13][C:14]#[N:15])[CH:5]=1)#[N:2].Cl.N[C:18]1[C:23]([F:24])=[C:22]([F:25])[CH:21]=[C:20]([F:26])[C:19]=1[SH:27]>>[F:24][C:23]1[C:18]2[N:2]=[C:1]([CH2:3][C:4]3[CH:5]=[C:6]([CH2:13][C:14]#[N:15])[CH:7]=[C:8]([N:10]([CH3:11])[CH3:12])[CH:9]=3)[S:27][C:19]=2[C:20]([F:26])=[CH:21][C:22]=1[F:25]

Participants

3

Reactant 2

HCID 11390282Benzenethiol, 2-amino-3,4,6-trifluoro-, hydrochlorideHCID 57307003HCID 57307003, compound

Product 1

HCID 21463536HCID 21463536, compoundYield 30%

Procedure

The procedure of Example 22-i) was repeated using 1,3-biscyanomethyl-5-dimethylaminobenzene (440 mg, 2.2 mmol) and 2-amino-3,4,6-trifluorothiophenol hydrochloride (474 mg, 2.2 mmol) and the resultant product was crystallized from isopropyl ether to give 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-5-dimethylaminophenylacetonitrile (234 mg, 30%) as a colorless powder.

Workup

  1. customthe resultant product was crystallized from isopropyl ether

Sources & evidence

ORD record
ord-5dc7c5eba8a6477ba789ff02dbc0296a
Source dataset
uspto-grants-1997_12
Patent number
US05700819

Reaction notes

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