Triethylamine → HCID 86749741, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.88 g(7.28 mmol) of the alcohol 2 in 32 mL dichloromethane at 0° C. was treated with 1.29 g(1.77 mL, 12.7 mmol) of triethylamine followed by addition of 1.04 g(0.70 mL, 9.10 mmol) of methanesulfonylchloride. The solution was stirred at 0° C. for 15 min, followed by dilution with dichloromethane and extraction with water. The solution was dried (Na2SO4) and concentrated in vacuo to afford 3.4 g(98%) of the mesylate 3 as a light pink solid (high resolution mass spectrum: calcd for C20H28FN3O7S: 473.1632. found: 473.1631), sufficiently pure for use in the next step.

Provenance & Evidence