Aluminum(III) Chloride → HCID 136048655, compound

HRID 1940745Notes

Reaction equation

HRID 1940745 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([Cl:22])[CH:15]=2)[N:11]([CH3:23])[N:10]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([Cl:22])[CH:15]=2)[N:11]([CH3:23])[N:10]=1

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 214636823-(2-chloro-6-fluorophenyl)-5-(3-chloro-4-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

Product 1

HCID 136048655HCID 136048655, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To benzene (300 ml) are added the crude product of 3-(2-chloro-6-fluorophenyl)-5-(3-chloro-4-methoxyphenyl)-1-methyl-1H-1,2,4-triazole (70.5 g) and anhydrous aluminum chloride (80.0 g), which are heated under reflux for 3 hours with stirring. After cooling to room temperature, the reaction mixture is poured into ice water and extracted with toluene. The organic layer is washed with water, extracted with aqueous solution of 20% NaOH, and the aqueous layer is acidified by adding a concentrated sulfuric acid little by little while cooling with ice and extracted with ethyl acetate. The organic layer is washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 64.2 g of desired compound.

Workup

  1. temperatureare heated
  2. temperatureunder reflux for 3 hours
  3. extractionextracted with toluene
  4. washThe organic layer is washed with water
  5. extractionextracted with aqueous solution of 20% NaOH
  6. additionby adding a concentrated sulfuric acid little by little
  7. temperaturewhile cooling with ice
  8. extractionextracted with ethyl acetate
  9. washThe organic layer is washed with water
  10. dry with materialdried over anhydrous magnesium sulfate
  11. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3d48c172fcae47fa96d3a203cff3759b
Source dataset
uspto-grants-1997_12
Patent number
US05700824

Reaction notes

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