Thionyl Chloride → o-Tolyl-acetyl chloride
Reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8](O)=[O:9].S(Cl)([Cl:14])=O>>[CH3:11][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([Cl:14])=[O:9]Participants
3
Procedure
A solution of 2.0 g of o-tolylacetic acid in 27 ml of thionyl chloride is heated at reflux for 1 hour. The volatiles are evaporated in vacuo to give a residue which is concentrated from toluene three times and dried under vacuum to give 2.1 g of the desired product as a light brown oil.
Workup
- temperatureat reflux for 1 hour
- customThe volatiles are evaporated in vacuo
- customto give a residue which
- concentrationis concentrated from toluene three times
- customdried under vacuum
Sources & evidence
- ORD record
- ord-bdb690a4fdd84212aeadba5b14725da8
- Source dataset
- uspto-grants-1997_12
- Patent number
- US05700796
Reaction notes
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