Methanol → 3-[Carboxymethyl-(4-chloro-benzyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 194085Notes

Reaction equation

HRID 194085 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([N:13]([CH2:14][C:15](=[O:16])[O:17][CH3:18])[CH2:19][c:20]2[cH:21][cH:22][c:23]([Cl:26])[cH:24][cH:25]2)[CH2:11][CH2:12]1.[CH3:27][OH:28].[Na+:30].[OH-:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([N:13]([CH2:14][C:15](=[O:16])[OH:17])[CH2:19][c:20]2[cH:21][cH:22][c:23]([Cl:26])[cH:24][cH:25]2)[CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 667583843-[(4-Chloro-benzyl)-methoxycarbonylmethyl-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 667583453-[Carboxymethyl-(4-chloro-benzyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-a14abb001d9a4cc39651eb3b28af1768
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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