Water → HCID 21275882, compound

Participants

Reaction Steps

Acryloyl chloride (19 g) was dissolved in THF (200 mL) in a 1 L flask and placed in an ice bath. A solution containing dodecylamine (37.1 g), triethylamine (20.2 g) and THF (300 mL) was added dropwise, maintaining the temperature at 5°-15° C. After addition the solution was stirred for 5 minutes and the solid was filtered off and discarded. The solvent was removed in vacuo from the mother liquor and methanol (50 mL) was added to the residue. After stirring, water (200 mL) was added and crystals formed. Additional water (200 mL) was added, the solution was stirred for 30 minutes, and the solid was filtered off. The solid was vacuum dried at room temperature to yield 40.3 g.

Provenance & Evidence