Hydrochloric Acid → HCID 21459586, compound

Participants

Reaction Steps

898 mg (2.03 mmol) of the ester obtained in Example 6, in 25 ml of methanol, were treated with 2 g of sodium hydroxide. The reaction mixture was maintained under stirring for 48 hours. The reaction mixture was poured into ice-cold water, acidified to pH 1 with concentrated hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate, filtered and evaporated to yield 951 mg (92%) of the expected compound, melting at 146°-148° C.

Provenance & Evidence