Tetrahydrofuran → HCID 21459436, compound

Participants

Reaction Conditions

Reaction Steps

Dried THF (100 ml) was added to lithium aluminum hydride (17.6 g, 0.464 mol), followed by cooling the mixture down to 0° C., dropwise adding thereto a 800 ml THF solution of the above 4-(1,4-dioxaspiro[4.5]decyl)cyclohexylmethanoic acid ethyl ester (183.2 g, 0.464 mol), stirring at 0° C. for 3 hours, stirring at room temperature for 2 hours, washing the reaction solution successively with 3N HCl, a saturated aqueous solution of sodium bicarbonate and water, distilling off the solvent, and recrystallizing, to isolate colorless crystals of 2-(4-(1,4-dioxaspiro[4,5]decyl)cyclohexyl)ethanol (50.6 g, 0,179mol). Yield from bicyclohexanedione monoethylene ketal was 38%.

Provenance & Evidence