反应详情

Formic acid (3.0 g, 66 mmol) and toluene (20 ml) were added to the above 4-(4-(1,3-dioxan-2-ylethyl)cyclohexyl)-1-(2-(4-trifluoromethoxyphenyl)ethyl)cyclohexane (3.25 g, 6.94 mmol), followed by refluxing the mixture for 5 hours, washing the organic layer successively with a saturated, aqueous solution of sodium bicarbonate and water, drying over magnesium sulfate, and distilling off the solvent, to obtain 3-(4-(4-(2-(4-trifluoromethoxyphenyl)ethyl)cyclohexyl)cyclohexyl)propanal (2.70 g, 6.58 mmol). Yield: 94.8%.

1. temperatureby refluxing the mixture for 5 hours
2. washwashing the organic layer successively with a saturated, aqueous solution of sodium bicarbonate and water
3. dry with materialdrying over magnesium sulfate
4. distillationdistilling off the solvent