反应详情

温度

0 °C

Ethanol (20 ml) was added to the above 3-(4-(4-(2-(4-trifluoromethoxyphenyl)ethyl)cyclohexyl)cyclohexyl) propanal (2.70 g, 6.58 mmol), followed by cooling the mixture down to 0° C. in a nitrogen gas atmosphere, adding thereto, sodiumboronhydride (0.13 g, 3,43 mmol) so that the liquid temperature could not exceed 10° C., stirring the mixture at 0° C. for 2 hours, extracting the resulting product with ethyl acetate, washing the organic layer successively with a saturated aqueous solution of sodium bicarbonate and water, drying over magnesium sulfate, distilling off the solvent, and recrystallizing the residue from heptane, to obtain 3-(4-(4-(2-(4-trifluoromethoxyphenyl)ethyl)cyclohexyl)cyclohexyl)propanol (2.10 g, 5.09 mmol). Yield: 77.4%.

1. additionadding
2. customexceed 10° C.
3. extractionextracting the resulting product with ethyl acetate
4. washwashing the organic layer successively with a saturated aqueous solution of sodium bicarbonate and water
5. dry with materialdrying over magnesium sulfate
6. distillationdistilling off the solvent
7. customrecrystallizing the residue from heptane