HCID 21459434, compound → HCID 21459447, compound

Participants

Reaction Conditions

Reaction Steps

Ethanol (12 ml) was added to the above 3-(4-(2-(3-fluoro-4-trifluoromethoxyphenyl)ethyl)cyclohexyl)propanal (1.76 g, 5.1 mmol), followed by cooling the mixture down to 0° C. in a nitrogen gas atmosphere, adding to the mixture, sodiumboron hydride (0.19 g, 5.0 mmol) so that the liquid temperature might not exceed 10° C., stirring the mixture at 0° C. for 2 hours, extracting the resulting product with ethyl acetate, washing the organic layer successively with a saturated, aqueous solution of sodium bicarbonate and water, drying over MgSO4, distilling off the solvent, and recrystallizing the residue with heptane, to obtain 3-(4-(2-(3-fluoro-4-trifluoromethoxyphenyl)ethyl)cyclohexyl)propanol (1.52 g, 4.4 mmol). Yield: 86.3%.

Provenance & Evidence