Dicyclohexylcarbodiimide → 2,5-Dioxopyrrolidin-1-YL 4-hydroxy-3,5-dimethylbenzoate

HRID 1941084Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:12])[C:10]=1[OH:11])[C:5]([OH:7])=[O:6].O[N:14]1[C:18](=[O:19])[CH2:17][CH2:16][C:15]1=[O:20].C1(N=C=NC2CCCCC2)CCCCC1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:12])[C:10]=1[OH:11])[C:5]([O:7][N:14]1[C:18](=[O:19])[CH2:17][CH2:16][C:15]1=[O:20])=[O:6]

Participants

Reactant 3

HCID 10868Dicyclohexylcarbodiimide

HCID 80170N-Hydroxysuccinimide

HCID 1383874-Hydroxy-3,5-dimethylbenzoic acid

Product 1

HCID 713509902,5-Dioxopyrrolidin-1-YL 4-hydroxy-3,5-dimethylbenzoate

Procedure

treating 3,5-dimethyl-4-hydroxybenzoic acid with N-hydroxysuccinimide and 1,3-dicyclohexylcarbodiimide to produce succinimidyl 3,5-dimethyl-4-hydroxybenzoate;

Sources & evidence

ORD record: ord-55f19aab99cb46af9a20b436ed084ce9
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05702887

Reaction notes

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