HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 3-(2-bromoethyl)-5-methoxy-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-Methoxytryptophol | HCID 12835 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(2-bromoethyl)-5-methoxy-1H-indole | HCID 11107868 | — |
Reaction Steps
A mixture of 10 g of the product obtained in Stage 1 (0.0523 mol), 16.5 g of triphenylphosphine (0.0628 mol), 17.3 g of carbon tetrabromide (0.0628 mol) and 200 ml of acetonitrile is left stirring for 2 hours. The solvent is then evaporated under vacuum and the product purified by chromatography on a silica column, Merck 70-230 mesh, using dichloromethane as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703070 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-20399b95160f41c9befc8c8939316f52 |
| Source note | uspto-grants-1997_12 |