Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 10673254 | HCID 10673254 | — |
| Solvent | Water | HCID 962 | — |
| Product | 86023-87-2 | HCID 158910 | — |
Reaction Steps
A glass lined reactor was charged with 12.4 Kg of (3β,5α,11β,25R)-11-bromospirostan-3-ol-12-one (24.34 mole), 33 gallons of t-butanol, 33 gallons of water and 7.5 Kg (189 mole, 7.75 eq) of sodium hydroxide pellets. The reaction was heated to reflux over 1.5 hours, maintained at reflux for 4.5 hours (pot temperature was 83° C.), then cooled to room temperature. TLC at this point indicated complete reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05703052 |
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| Source dataset | uspto-grants-1997_12 |
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| ORD ID | ord-27d33e0bf4c940a1bf0b7580e434818d |
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| Source note | uspto-grants-1997_12 |
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