Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 21460403 | HCID 21460403 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21460394 | HCID 21460394 | — |
Reaction Steps
A solution of 2-azido-N-(2-Benzyloxyethyl)-2-methylpropionamide (70 g) in THF (750 ml) was added to a suspension of LiAlH4 (20 g) in THF (500 ml) at 0° C. during 1 h. After reflux for 4 h, the mixture was cooled to 0° C., water (20 ml) and aqueous NaOH (20 ml) were added, the inorganic salts were filtered off and the solvents were dried. Evaporation of the solvents in vacuo gave 8a as an oil: 53 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05703087 |
|---|
| Source dataset | uspto-grants-1997_12 |
|---|
| ORD ID | ord-7cb9f0884a26407d92f28455a614f6d8 |
|---|
| Source note | uspto-grants-1997_12 |
|---|
