Water → HCID 21460407, compound

Participants

Reaction Steps

A solution of 9a (28 g) in THF (250 ml) was added to a suspension of LiAlH4 (8 g) in THF (250 ml) at 20°-25° C. After stirring at room temperature for 1 h, the mixture was cooled to 0° C., water (10 ml) and aqueous NaOH (10 ml) were added, the inorganic salts were filtered and the solvents were evaporated in vacuo. The remaining oil was purified by column chromatography on silica gel (ethyl acetate) yielding 9b as an oil: 10 g.

Provenance & Evidence