反应详情

To a stirred solid of sodium borohydride (37 grams, 978 mmol) at 0° C., was added methanol (50 mL). To this mixture at 0° C. was added a solution of methyl 3-amino-3-(3'-cyclopentyloxy-4'-methoxyphenyl)propionate (27 grams, 92.2 mmol) in methanol (500 mL) over 1 h. The mixture was stirred in that ice-water bath until the temperature of the reaction mixture stayed at 35° C. or lower for 30 minutes. (Caution: If the ice-water bath was removed too early, a highly exothermic reaction may occur.) The water bath was then removed and the solution was refluxed for 16 h. The solution was allowed to cool to room temperature. To the solution was added water (125 mL), followed by methylene chloride (250 mL) at 0° C. The resulting suspension was filtered. Half of the filtrate was removed in vacuo. The resulting solution was dissolved in methylene chloride (250 mL) and water (200 mL). The organic layer was separated. The aqueous layer was extracted with methylene chloride (3×250 mL). The combined organic layers were washed with brine (100 mL), and dried over magnesium sulfate. Removal of solvent gave an oil. The resulting oil was dried in vacuo to afford 3-amino-3-(3'-cyclopentyloxy-4'-methoxyphenyl)-1-propanol as a white solid (22.3 grams, 91% yield): mp, 216.0°-217.5° C.; 1H NMR (CDCl3)δ1.52-1.68 (m, 2H, CH2), 1.76-1.91 (m, 8H, C5H8), 2.92 (brs, 3H, NH2, OH), 3.76 (t, J=5.5 Hz, 2H, CH2), 3.82 (s, 3H, CH3), 4.06 (t, J=Hz, 1H, OCH), 4.76-4.79 (m, 1H, NCH), 6.82-6.84 (m, 3H, Ar); 13C NMR (CDCl3)δ23.96, 32.75, 39.91, 55.59, 56.10, 61.62, 80.46, 112.11, 112.99, 117.75, 138.65, 147.74, 149.12; Anal Calcd for C15H23NO3 0.05CH2Cl2 : C, 67.05; H, 8.64, N, 5.20. Found: C, 67.02; H, 8.41; N, 5.08.

1. custom(Caution: If the ice-water bath was removed too early
2. customa highly exothermic reaction
3. custom) The water bath was then removed
4. temperaturethe solution was refluxed for 16 h
5. additionTo the solution was added water (125 mL)
6. customfollowed by methylene chloride (250 mL) at 0° C
7. filtrationThe resulting suspension was filtered
8. customHalf of the filtrate was removed in vacuo
9. dissolutionThe resulting solution was dissolved in methylene chloride (250 mL)
10. customThe organic layer was separated
11. extractionThe aqueous layer was extracted with methylene chloride (3×250 mL)
12. washThe combined organic layers were washed with brine (100 mL)
13. dry with materialdried over magnesium sulfate
14. customRemoval of solvent
15. customgave an oil
16. customThe resulting oil was dried in vacuo